High-dose hook effect

"High-dose hook effect" with the Centocor CA 125 assay.

Supplemental Information: Cooperative Binding Mitigates the High-Dose Hook Effect

In order to explore how the high-dose Hook effect is dependent on the parameters used in our model, we repeated the simulations done for the figure entitled “Reduced hook effect in cooperative (wt) calmodulin” with a range of parameter values. First, we varied all dissociation constants by factors of 10. The results (see figure 1) show that a high-dose Hook effect is observed in all the cases. ...

High-Dose Hook Effect in 17-Hydroxyprogesterone Assay in a Patient with 21-Hydroxylase Deficiency.

Congenital adrenal hyperplasia (CAH) describes a group of disorders characterized by enzyme defects in adrenal steroidogenesis. 21-hydroxylase deficiency (21-OHD) is the most commonly encountered form. The analysis of steroids in pediatric cases requires high-sensitivity assays. A 14-year-old Syrian girl was referred for evaluation of short stature, amenorrhea, and hirsutism. On physical examin...

Three commercial methods for serum ferritin compared and the high-dose "hook effect" eliminated.

We evaluated four commercial kits for measuring serum ferritin, based on three techniques: immunoradiometric assay, radioimmunoassay, and enzyme immunoassay. The kits evaluated were those manufactured by Abbott Laboratories, Clinical Assays, Corning Medical, and Ramco. Two of the immunoradiometric kits showed satisfactory results with respect to sensitivity and precision; they should be useful ...

Applicator Attenuation Effect on Dose Calculations of Esophageal High-Dose Rate Brachytherapy Using EDR2 Film

Introduction Interaluminal brachytherapy is one of the important methods of esophageal cancer treatment. The effect of applicator attenuation is not considered in dose calculation method released by AAPM-TG43. In this study, the effect of High-Dose Rate (HDR) brachytherapy esophageal applicator on dose distribution was surveyed in HDR brachytherapy. Materials and Methods A cylindrical PMMA phan...